Mr. Natural is a multi-part crime drama starring Robert De Niro in the lead role. The story revolves around an aging respected figure in the criminal world named Louis Baron. Once known for his determination and fearlessness, he earned the nickname Mr. Natural. However, for the past three decades, the protagonist has been behind bars, paying for his past sins. After being released early, Louis heads to his hometown of Palm Springs, California, to gather his supporters once again.