"Murdaugh Murders: A Southern Scandal" is a detective drama that follows the investigation of a high-profile series of crimes. The events take place in the southeastern United States, in the state of South Carolina. The local police have been trying to catch a nearby serial killer who leaves behind blood and bodies of innocent people. However, the case only gains momentum when another crime attracts the attention of detectives from the capital. The evidence leads to the most powerful family in the city.