The Doctor Blake Mysteries revolves around a doctor named Lucien Blake, who left his hometown of Ballarat at a young age. However, he returns after some time to take over his late father's position as a doctor who also attended crime scenes. The late 1950s were marked by a gold rush, which is responsible for the city's magnificent architecture. But it is also a time of secrets, murders, and deceit, which Dr. Blake will have to confront.