The story revolves around a talented young man named Edward and his younger brother Alphonse. They are both deeply fascinated by alchemical experiments and achieve notable success in this field. When their mother dies, the boys attempt to resurrect her using their gift, but their efforts are unsuccessful. As a result, Edward loses two of his limbs and barely manages to save Alphonse by binding his soul to a suit of armor. Now, the heroes must find the Philosopher's Stone to regain their bodies.