The events in the historical drama series "Jamestown" take place in the first half of the 17th century. The story revolves around English colonists who arrive on ships to the American continent to establish settlements. In 1607, the Jamestown colony is founded, marking the beginning of the New World. Three English women sail on a ship to meet their future husbands. The young women are unaware of what this journey will bring them in their new lives.