The story of an airplane crash in which 48 passengers find themselves on an unknown island somewhere in the Pacific Ocean. Panic ensues as everyone tries to find their loved ones and make sense of the tragedy. There is little hope of escaping this place, so the survivors must gather their strength and try to stay alive, adapting to completely new conditions. The island, in turn, holds many mystical mysteries and unexplained phenomena that will constantly confuse the characters throughout the series.