"Radio Romance" is a series about the relationships of childhood friends who reunite. Son Gye Rim has always dreamed of working at a radio station because of her mother's blindness. As an adult, she manages to make her dream come true, but her program is on the verge of being cancelled due to a lack of listeners. Her boss informs her that he will reconsider if she can convince the popular and arrogant actor, Chi Su Ho, to host the show.